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He later enrolled in Barts and The London School of Medicine and Dentistry at Queen Mary, University of London, to study Medicine before he dropped out in 2003 to pursue a singing career.
For his music career, he chose the stage name Jay Sean; "Jay" being his nickname, while "Sean" is derived from "Shaan"—a nickname he was called at home by his grandmother—which means "shining star" or "pride" in Punjabi.
His American-debut single was "Down" featuring American rapper and label mate Lil Wayne.
It topped the Billboard Hot 100, replacing The Black Eyed Peas.
Sean has also been a featured artist on several hits including "What Happened to Us" by Australian singer Jessica Mauboy, which charted within the top 20 on the ARIA singles chart and certified platinum by the Australian Recording Industry Association. At age 11, he and his cousin Pritpal Rupra formed a hip hop duo named "Compulsive Disorder".
His stage name at the time was MC "Nicky J", with the "J" being derived from the first letter of his last name "Jhooti".
It was followed by hits such as "Maybe", which reached No."Ride It" was successful in Eastern Europe, especially in Russia, A Mandarin Chinese cover version of "Maybe" by Coco Lee has been released in China.Sean sang a Hindi version of the album My Own Way for release in India.Despite this, it has become his highest-charting album in Japan, reaching No. Three singles, "2012 (It Ain't the End)", "Hit The Lights" and "Like This, Like That" were released in support of the album.Sean also co-headlined with Joe Jonas on the Joe Jonas & Jay Sean Tour with Jo Jo as the opening act.
the Rishi Rich Project was formed (consisting of Rich, Sean and Juggy D) in 2003.